The Vagus Nerve: Your Key To Health

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The Vagus Nerve: Your Key To Health

Vaga in Latin means “to wander”. The vagus nerve is the longest cranial nerve within our autonomic nervous system that wanders from the brain, through the body, to the abdomen [1]. The vagus nerve is the main part of the parasympathetic nervous system.

When the vagus nerve is not functioning optimally, it can lead to depression, anxiety, obesity, cardiovascular disorders, hypertension, digestive disorders, kidney malfunction, infertility, chronic inflammation, diabetes, and even Parkinson’s disease [1,2,3,4,5,6,7,8].

The malfunctioning of the vagus nerve can be caused by stress, improper diet, alcohol, and lack of exercise. 

The vagus nerve is such a crucial component to depression treatment that in severe cases, it is stimulated by medical professionals using an electrode. The vagus nerve is a major contributor to depression and anxiety treatment [9,10]. Activation of the nervous system results in increased happiness, relaxation, better sleep, and improved immunity function. Studies have shown that vagus nerve activation treated depression, even in treatment-resistant cases [11]. 

The most effective way to activate the vagus nerve is with breathing techniques. Additionally, it can be stimulated by splashing cold water on your face, humming or chanting, exercise, yoga, probiotics, laughing, and affection [12]. 

  1. Kenny, B. J., & Bordoni, B. (2021). Neuroanatomy, Cranial Nerve 10 (Vagus Nerve). In StatPearls. StatPearls Publishing.
  2. Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018). Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders. Frontiers in psychiatry, 9, 44. https://doi.org/10.3389/fpsyt.2018.00044
  3. de Lartigue G. (2016). Role of the vagus nerve in the development and treatment of diet-induced obesity. The Journal of physiology, 594(20), 5791–5815. https://doi.org/10.1113/JP271538
  4. Tanaka, S., & Okusa, M. D. (2020). Crosstalk between the nervous system and the kidney. Kidney international, 97(3), 466–476. https://doi.org/10.1016/j.kint.2019.10.032
  5. Derakhshan, N., Yaghmaei, S., & Keshavarz, P. (2021). Vagal nerve stimulation for the treatment of male factor infertility. Andrologia, 53(6), e14043. https://doi.org/10.1111/and.14043
  6. Pavlov, V. A., & Tracey, K. J. (2012). The vagus nerve and the inflammatory reflex–linking immunity and metabolism. Nature reviews. Endocrinology, 8(12), 743–754. https://doi.org/10.1038/nrendo.2012.189
  7. Payne, S. C., Ward, G., MacIsaac, R. J., Hyakumura, T., Fallon, J. B., & Villalobos, J. (2020). Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions. Physiological reports, 8(11), e14479. https://doi.org/10.14814/phy2.14479
  8. Walter, U., Tsiberidou, P., Kersten, M., Storch, A., & Löhle, M. (2018). Atrophy of the Vagus Nerve in Parkinson’s Disease Revealed by High-Resolution Ultrasonography. Frontiers in neurology, 9, 805. https://doi.org/10.3389/fneur.2018.00805
  9. Bremner, J. D., Gurel, N. Z., Wittbrodt, M. T., Shandhi, M. H., Rapaport, M. H., Nye, J. A., Pearce, B. D., Vaccarino, V., Shah, A. J., Park, J., Bikson, M., & Inan, O. T. (2020). Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders. Journal of personalized medicine, 10(3), 119. https://doi.org/10.3390/jpm10030119
  10. Fanselow M. S. (2013). Fear and anxiety take a double hit from vagal nerve stimulation. Biological psychiatry, 73(11), 1043–1044. https://doi.org/10.1016/j.biopsych.2013.03.025
  11. O’Reardon, J. P., Cristancho, P., & Peshek, A. D. (2006). Vagus Nerve Stimulation (VNS) and Treatment of Depression: To the Brainstem and Beyond. Psychiatry (Edgmont (Pa. : Township)), 3(5), 54–63.
  12. Yuan, H., & Silberstein, S. D. (2016). Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part I. Headache, 56(1), 71–78. https://doi.org/10.1111/head.12647

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